| Reaction Details |
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 | Report a problem with these data |
| Target | Acidic mammalian chitinase |
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| Ligand | BDBM50243795 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1985608 (CHEMBL4619014) |
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| IC50 | 3.0±n/a nM |
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| Citation |  Andryianau, G; Kowalski, M; Piotrowicz, MC; Rajkiewicz, AA; Dymek, B; Sklepkiewicz, PL; Pluta, E; Stefaniak, F; Czestkowski, W; Olejniczak, S; Mazur, M; Niedziejko, P; Koralewski, R; Matyszewski, K; Gruza, M; Zagozdzon, A; Salamon, M; Rymaszewska, A; Welzer, M; Dzwonek, K; Golab, J; Olczak, J; Bartoszewicz, A; Golebiowski, A Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett11:1228-1235 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acidic mammalian chitinase |
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| Name: | Acidic mammalian chitinase |
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| Synonyms: | AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902 |
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| Type: | Protein |
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| Mol. Mass.: | 52266.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BZP6 |
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| Residue: | 476 |
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| Sequence: | MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAG
RQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFI
TSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMV
TAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAY
LNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGI
WAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVW
AIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSS
GGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
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| BDBM50243795 |
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| n/a |
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| Name | BDBM50243795 |
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| Synonyms: | CHEMBL4077644 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26Cl2N6 |
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| Mol. Mass. | 445.388 |
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| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1Cl |
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| Structure | 
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