| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 8 |
|---|
| Ligand | BDBM50543465 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1989198 (CHEMBL4622745) |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Mussari, CP; Dodd, DS; Sreekantha, RK; Pasunoori, L; Wan, H; Posy, SL; Critton, D; Ruepp, S; Subramanian, M; Watson, A; Davies, P; Schieven, GL; Salter-Cid, LM; Srivastava, R; Tagore, DM; Dudhgaonkar, S; Poss, MA; Carter, PH; Dyckman, AJ Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett11:1751-1758 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 8 |
|---|
| Name: | Toll-like receptor 8 |
|---|
| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 119828.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NR97 |
|---|
| Residue: | 1041 |
|---|
| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
|
|
|
|---|
| BDBM50543465 |
|---|
| n/a |
|---|
| Name | BDBM50543465 |
|---|
| Synonyms: | CHEMBL4636498 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H37N3O2 |
|---|
| Mol. Mass. | 435.6016 |
|---|
| SMILES | CNCCN1CCC(CC1)c1ccc2[nH]c(c(C(C)C)c2c1)-c1ccc(OC)c(OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
