| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 7 |
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| Ligand | BDBM50543493 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1989194 (CHEMBL4622741) |
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| IC50 | >10000±n/a nM |
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| Citation |  Mussari, CP; Dodd, DS; Sreekantha, RK; Pasunoori, L; Wan, H; Posy, SL; Critton, D; Ruepp, S; Subramanian, M; Watson, A; Davies, P; Schieven, GL; Salter-Cid, LM; Srivastava, R; Tagore, DM; Dudhgaonkar, S; Poss, MA; Carter, PH; Dyckman, AJ Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett11:1751-1758 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 7 |
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| Name: | Toll-like receptor 7 |
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| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
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| Type: | Enzyme |
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| Mol. Mass.: | 120945.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYK1 |
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| Residue: | 1049 |
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| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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| BDBM50543493 |
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| n/a |
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| Name | BDBM50543493 |
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| Synonyms: | CHEMBL4649118 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O |
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| Mol. Mass. | 377.5224 |
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| SMILES | CNCCN1CCC(CC1)c1ccc2[nH]c(c(C)c2c1)-c1ccccc1OC |
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| Structure | 
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