Reaction Details |
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Target | Adenosine kinase |
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Ligand | BDBM50100583 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31125 (CHEMBL643553) |
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IC50 | 91.7±n/a nM |
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Citation | Lee, CH; Jiang, M; Cowart, M; Gfesser, G; Perner, R; Kim, KH; Gu, YG; Williams, M; Jarvis, MF; Kowaluk, EA; Stewart, AO; Bhagwat, SS Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem44:2133-8 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine kinase |
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Name: | Adenosine kinase |
Synonyms: | ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk |
Type: | Enzyme |
Mol. Mass.: | 40130.14 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat brain cytosol as enzyme source. |
Residue: | 361 |
Sequence: | MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDK
HKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAA
DAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARV
YYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNE
TEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPV
LDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDF
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BDBM50100583 |
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n/a |
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Name | BDBM50100583 |
Synonyms: | 7-(4-Dimethylamino-phenyl)-6-(4-methoxy-phenyl)-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL302938 |
Type | Small organic molecule |
Emp. Form. | C22H21N5O |
Mol. Mass. | 371.435 |
SMILES | COc1ccc(cc1)-c1cc2c(N)ncnc2nc1-c1ccc(cc1)N(C)C |
Structure |
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