| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine kinase |
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| Ligand | BDBM50100587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_88738 (CHEMBL700683) |
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| IC50 | 26000±n/a nM |
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| Citation |  Lee, CH; Jiang, M; Cowart, M; Gfesser, G; Perner, R; Kim, KH; Gu, YG; Williams, M; Jarvis, MF; Kowaluk, EA; Stewart, AO; Bhagwat, SS Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem44:2133-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Adenosine kinase |
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| Name: | Adenosine kinase |
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| Synonyms: | ADK | ADK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40545.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467841 |
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| Residue: | 362 |
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| Sequence: | MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
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| BDBM50100587 |
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| n/a |
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| Name | BDBM50100587 |
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| Synonyms: | (2R,3R,4S,5R)-2-(6-Amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | 2-(6-Amino-5-nitro-pyrimidin-4-ylamino)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | CHEMBL304179 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H13N5O6 |
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| Mol. Mass. | 287.2294 |
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| SMILES | Nc1ncnc(N[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1[N+]([O-])=O |
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| Structure | 
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