Ki Summary

Reaction Details

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Target

Adenosine kinase

Ligand

BDBM50090895

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_88738 (CHEMBL700683)

IC50

134±n/a nM

Citation

Lee, CH; Jiang, M; Cowart, M; Gfesser, G; Perner, R; Kim, KH; Gu, YG; Williams, M; Jarvis, MF; Kowaluk, EA; Stewart, AO; Bhagwat, SS Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem44:2133-8 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Adenosine kinase

Name:

Adenosine kinase

Synonyms:

ADK | ADK_HUMAN

Type:

PROTEIN

Mol. Mass.:

40545.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1467841

Residue:

362

Sequence:

MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

BDBM50090895

n/a

Name

BDBM50090895

Synonyms:

(2R,3R,4S,5R)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | (2S,3S,4R,5S)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | 2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | 4-(4-fluorophenylamino)-5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine | CHEMBL66277

Type

Small organic molecule

Emp. Form.

C23H21FN4O3

Mol. Mass.

420.4362

SMILES

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(-c2ccccc2)c2c(Nc3ccc(F)cc3)ncnc12

Structure