| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine kinase |
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| Ligand | BDBM50100586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31125 (CHEMBL643553) |
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| IC50 | 66.7±n/a nM |
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| Citation |  Lee, CH; Jiang, M; Cowart, M; Gfesser, G; Perner, R; Kim, KH; Gu, YG; Williams, M; Jarvis, MF; Kowaluk, EA; Stewart, AO; Bhagwat, SS Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. J Med Chem44:2133-8 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine kinase |
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| Name: | Adenosine kinase |
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| Synonyms: | ADENOSINE | ADK_RAT | Adenosine 5-phosphotransferase | Adenosine Kinase (AK) | Adenosine kinase | Adk |
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| Type: | Enzyme |
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| Mol. Mass.: | 40130.14 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat brain cytosol as enzyme source. |
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| Residue: | 361 |
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| Sequence: | MAAADEPKPKKLKVEAPEALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDK
HKELFDELVKKFKVEYHAGGSTQNSMKVAQWMIQEPHRAATFFGCIGIDKFGEILKSKAA
DAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLENNWMLVEKARV
YYIAGFFLTVSPESVLKVARYAAENNRTFTLNLSAPFISQFFKEALMEVMPYVDILFGNE
TEAATFAREQGFETKDIKEIARKTQALPKVNSKRQRTVIFTQGRDDTIVATGNDVTAFPV
LDQNQEEIVDTNGAGDAFVGGFLSQLVSNKPLTECIRAGHYAASVIIRRTGCTFPEKPDF
H
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| BDBM50100586 |
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| n/a |
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| Name | BDBM50100586 |
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| Synonyms: | 3-[4-Amino-7-(4-dimethylamino-phenyl)-pyrido[2,3-d]pyrimidin-6-yl]-benzoic acid methyl ester | CHEMBL416498 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N5O2 |
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| Mol. Mass. | 399.4451 |
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| SMILES | COC(=O)c1cccc(c1)-c1cc2c(N)ncnc2nc1-c1ccc(cc1)N(C)C |
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| Structure | 
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