| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-protein thioesterase 1 |
|---|
| Ligand | BDBM50543970 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1990947 (CHEMBL4624682) |
|---|
| IC50 | 1504±n/a nM |
|---|
| Citation |  Zhang, B; Liu, F; Yang, MF; Xu, J; Wang, Z; Zhang, J; Wang, R; Yang, X A cell-based fluorescent assay for FAP inhibitor discovery. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-protein thioesterase 1 |
|---|
| Name: | Acyl-protein thioesterase 1 |
|---|
| Synonyms: | Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 24708.49 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_12731 |
|---|
| Residue: | 230 |
|---|
| Sequence: | MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMP
VTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLM
FGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
|
|
|
|---|
| BDBM50543970 |
|---|
| n/a |
|---|
| Name | BDBM50543970 |
|---|
| Synonyms: | CHEMBL4647532 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C45H39F2N7O8S |
|---|
| Mol. Mass. | 875.895 |
|---|
| SMILES | Oc1ccc2c(Oc3cc(O)ccc3C22OC(=O)c3cc(NC(=S)N4CCN(CCCOc5ccc6nccc(C(=O)NCC(=O)N7CC(F)(F)C[C@H]7C#N)c6c5)CC4)ccc23)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
