Reaction Details |
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Target | DNA (cytosine-5)-methyltransferase 3A |
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Ligand | BDBM50544058 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1991441 (CHEMBL4625176) |
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Kd | 1500±n/a nM |
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Citation | Sergeev, A; Vorobyov, A; Yakubovskaya, M; Kirsanova, O; Gromova, E Novel anticancer drug curaxin CBL0137 impairs DNA methylation by eukaryotic DNA methyltransferase Dnmt3a. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA (cytosine-5)-methyltransferase 3A |
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Name: | DNA (cytosine-5)-methyltransferase 3A |
Synonyms: | 2.1.1.- | 2.1.1.37 | Cysteine methyltransferase DNMT3A | DNA (cytosine-5)-methyltransferase 3A | DNA MTase MmuIIIA | DNA methyltransferase MmuIIIA | DNM3A_MOUSE | Dnmt3a |
Type: | PROTEIN |
Mol. Mass.: | 101671.89 |
Organism: | Mus musculus |
Description: | ChEMBL_108012 |
Residue: | 908 |
Sequence: | MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESS
DTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTET
PPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRP
MPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASP
PAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFS
WWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPM
YRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEP
PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVR
QKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGR
EVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSR
LQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASE
VCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLY
EGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKE
VSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGK
DQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
LKEYFACV
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BDBM50544058 |
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n/a |
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Name | BDBM50544058 |
Synonyms: | CHEMBL4640631 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O2 |
Mol. Mass. | 336.4275 |
SMILES | CC(C)NCCn1c2ccc(cc2c2cc(ccc12)C(C)=O)C(C)=O |
Structure |
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