Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50544724

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1993674 (CHEMBL4627569)

EC50

2470±n/a nM

Citation

Narayanan, S; Vasukuttan, V; Rajagopal, S; Maitra, R; Runyon, SP Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem28:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50544724

n/a

Name

BDBM50544724

Synonyms:

CHEMBL4641469

Type

Small organic molecule

Emp. Form.

C28H39N3O5

Mol. Mass.

497.6264

SMILES

COc1cccc(OC)c1-c1cc(nn1C1CCCC1)C(=O)N[C@@H](CCC1CCCCC1)CC(O)=O |r,wU:23.26,(40.31,-5.59,;40.93,-6.99,;40.03,-8.24,;38.5,-8.08,;37.59,-9.32,;38.21,-10.73,;39.75,-10.9,;40.37,-12.31,;39.47,-13.55,;40.66,-9.64,;42.19,-9.8,;43.22,-8.65,;44.63,-9.28,;44.47,-10.81,;42.96,-11.13,;42.35,-12.54,;40.85,-12.87,;40.69,-14.4,;42.1,-15.01,;43.12,-13.87,;45.96,-8.5,;45.96,-6.96,;47.3,-9.27,;48.63,-8.5,;48.63,-6.96,;49.96,-6.19,;49.96,-4.65,;51.29,-3.88,;51.29,-2.35,;49.96,-1.57,;48.62,-2.34,;48.62,-3.89,;49.96,-9.27,;51.3,-8.49,;52.63,-9.26,;51.29,-6.95,)|

Structure