Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50544722

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1993673 (CHEMBL4627568)

EC50

21±n/a nM

Citation

Narayanan, S; Vasukuttan, V; Rajagopal, S; Maitra, R; Runyon, SP Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem28:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50544722

n/a

Name

BDBM50544722

Synonyms:

CHEMBL4647332

Type

Small organic molecule

Emp. Form.

C29H36N4O6

Mol. Mass.

536.6193

SMILES

COC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(23.73,-48.34,;22.4,-49.11,;21.06,-48.34,;21.06,-46.8,;19.73,-49.12,;18.4,-48.35,;17.06,-49.12,;17.07,-50.66,;15.73,-48.35,;15.73,-46.81,;17.06,-46.04,;17.06,-44.5,;18.39,-43.73,;18.39,-42.2,;17.06,-41.42,;15.72,-42.19,;15.72,-43.74,;14.4,-49.12,;13.06,-48.36,;13.06,-46.82,;11.73,-49.13,;10.32,-48.5,;9.29,-49.65,;7.76,-49.5,;7.13,-48.09,;8.03,-46.85,;7.41,-45.44,;5.6,-47.93,;4.69,-49.18,;5.31,-50.59,;6.85,-50.75,;7.47,-52.16,;6.57,-53.4,;10.06,-50.98,;9.45,-52.39,;10.36,-53.63,;9.74,-55.04,;11.89,-53.46,;11.57,-50.66,)|

Structure