Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50544750

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1993673 (CHEMBL4627568)

EC50

>10000±n/a nM

Citation

Narayanan, S; Vasukuttan, V; Rajagopal, S; Maitra, R; Runyon, SP Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem28:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50544750

n/a

Name

BDBM50544750

Synonyms:

CHEMBL4633415

Type

Small organic molecule

Emp. Form.

C30H43N3O5

Mol. Mass.

525.6795

SMILES

COc1cccc(OC)c1-c1cc(nn1C1CCCCCC1)C(=O)N[C@@H](CCC1CCCCC1)CC(O)=O |r,wU:25.28,(36.85,-26.08,;37.47,-27.49,;36.57,-28.74,;35.04,-28.58,;34.13,-29.82,;34.75,-31.23,;36.28,-31.39,;36.86,-32.8,;36,-34.05,;37.2,-30.14,;38.73,-30.3,;39.76,-29.15,;41.17,-29.77,;41.01,-31.3,;39.51,-31.63,;38.88,-33.03,;39.88,-34.19,;39.6,-35.71,;38.24,-36.43,;36.84,-35.81,;36.44,-34.33,;37.35,-33.09,;42.51,-29,;42.5,-27.46,;43.84,-29.77,;45.17,-29,;45.17,-27.46,;46.5,-26.68,;46.5,-25.14,;47.83,-24.37,;47.83,-22.84,;46.5,-22.06,;45.16,-22.83,;45.16,-24.38,;46.51,-29.76,;47.84,-28.99,;49.18,-29.76,;47.84,-27.45,)|

Structure