Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50544730

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1993671 (CHEMBL4627566)

EC50

>10000±n/a nM

Citation

Narayanan, S; Vasukuttan, V; Rajagopal, S; Maitra, R; Runyon, SP Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem28:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50544730

n/a

Name

BDBM50544730

Synonyms:

CHEMBL4637936

Type

Small organic molecule

Emp. Form.

C26H31N3O5

Mol. Mass.

465.5414

SMILES

COc1cccc(OC)c1-c1cc(nn1CC(C)C)C(=O)N[C@@H](CCc1ccccc1)C(O)=O |r,wU:22.24,(67.18,-24.44,;67.81,-25.85,;66.9,-27.09,;65.37,-26.93,;64.46,-28.18,;65.08,-29.59,;66.62,-29.75,;67.25,-31.16,;66.34,-32.4,;67.53,-28.5,;69.06,-28.65,;70.09,-27.5,;71.5,-28.13,;71.34,-29.66,;69.84,-29.98,;69.22,-31.39,;70.13,-32.63,;69.51,-34.04,;71.66,-32.46,;72.83,-27.36,;72.83,-25.82,;74.17,-28.12,;75.5,-27.35,;75.5,-25.81,;76.83,-25.04,;76.83,-23.5,;78.16,-22.73,;78.16,-21.2,;76.83,-20.42,;75.49,-21.19,;75.49,-22.74,;76.84,-28.12,;78.17,-27.35,;76.84,-29.66,)|

Structure