| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM13022 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153305 (CHEMBL761982) |
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| Ki | 660.0±n/a nM |
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| Citation |  Grunewald, GL; Caldwell, TM; Li, Q; Criscione, KR Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. J Med Chem44:2849-56 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM13022 |
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| n/a |
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| Name | BDBM13022 |
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| Synonyms: | 3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | 7-sulfonamide-THIQ 12 | CHEMBL95873 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13FN2O2S |
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| Mol. Mass. | 244.286 |
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| SMILES | NS(=O)(=O)c1ccc2CC(CF)NCc2c1 |
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| Structure | 
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