| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Ligand | BDBM50545377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1994930 (CHEMBL4628825) |
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| IC50 | 158±n/a nM |
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| Citation |  Anderson, NA; Cryan, J; Ahmed, A; Dai, H; McGonagle, GA; Rozier, C; Benowitz, AB Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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| Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| Component 2 |
| Name: | G1/S-specific cyclin-D3 |
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| Synonyms: | CCND3 | CCND3_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 32521.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30281 |
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| Residue: | 292 |
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| Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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| BDBM50545377 |
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| n/a |
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| Name | BDBM50545377 |
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| Synonyms: | CHEMBL4640158 |
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| Type | Small organic molecule |
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| Emp. Form. | C55H73N11O9S |
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| Mol. Mass. | 1064.301 |
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| SMILES | C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCOCCOCCN1CCN(CC1)c1ccc(Nc2ncc3c(C)c(C(C)=O)c(=O)n(C4CCCC4)c3n2)nc1)C(C)(C)C)c1ccc(cc1)-c1nc(C)cs1 |r| |
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| Structure | 
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