| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50545767 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1996546 (CHEMBL4630441) |
|---|
| IC50 | 247±n/a nM |
|---|
| Citation |  Robles, O; Jackson, JJ; Marshall, L; Talay, O; Chian, D; Cutler, G; Diokno, R; Hu, DX; Jacobson, S; Karbarz, E; Kassner, PD; Ketcham, JM; McKinnell, J; Meleza, C; Reilly, MK; Riegler, E; Shunatona, HP; Wadsworth, A; Younai, A; Brockstedt, DG; Wustrow, DJ; Zibinsky, M Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors. J Med Chem63:8584-8607 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41406.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51679 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
|
|
|
|---|
| BDBM50545767 |
|---|
| n/a |
|---|
| Name | BDBM50545767 |
|---|
| Synonyms: | CHEMBL4640439 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H31Cl2N7O |
|---|
| Mol. Mass. | 516.466 |
|---|
| SMILES | C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(N)=O)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
