Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50546219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2014894 (CHEMBL4668472) |
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IC50 | >10000±n/a nM |
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Citation | Yuan, X; Bu, H; Zhou, J; Yang, CY; Zhang, H Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application. J Med Chem63:11368-11396 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50546219 |
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n/a |
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Name | BDBM50546219 |
Synonyms: | CHEMBL4752026 | US11596633, Compound B | US11702392, Compound RMC-4550 |
Type | Small organic molecule |
Emp. Form. | C21H26Cl2N4O2 |
Mol. Mass. | 437.363 |
SMILES | C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| |
Structure |
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