| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor ligand superfamily member 11 |
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| Ligand | BDBM50547336 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2017728 (CHEMBL4671306) |
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| IC50 | 2700±n/a nM |
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| Citation |  Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem63:12043-12059 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor ligand superfamily member 11 |
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| Name: | Tumor necrosis factor ligand superfamily member 11 |
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| Synonyms: | CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35484.75 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_106141 |
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| Residue: | 317 |
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| Sequence: | MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
PDQDATYFGAFKVRDID
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| BDBM50547336 |
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| n/a |
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| Name | BDBM50547336 |
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| Synonyms: | CHEMBL4745590 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N4O7S2 |
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| Mol. Mass. | 556.611 |
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| SMILES | CN(CCN(C)S(=O)(=O)c1ccccc1)C(=O)c1cn(c2ccccc12)S(=O)(=O)c1cccc(c1)[N+]([O-])=O |
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| Structure | 
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