| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tumor necrosis factor ligand superfamily member 11 |
|---|
| Ligand | BDBM50547346 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2017729 (CHEMBL4671307) |
|---|
| Kd | >11000±n/a nM |
|---|
| Citation |  Rinotas, V; Papakyriakou, A; Violitzi, F; Papaneophytou, C; Ouzouni, MD; Alexiou, P; Strongilos, A; Couladouros, E; Kontopidis, G; Eliopoulos, E; Douni, E Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-?B Ligand with a Superior Therapeutic Index. J Med Chem63:12043-12059 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tumor necrosis factor ligand superfamily member 11 |
|---|
| Name: | Tumor necrosis factor ligand superfamily member 11 |
|---|
| Synonyms: | CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35484.75 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_106141 |
|---|
| Residue: | 317 |
|---|
| Sequence: | MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
PDQDATYFGAFKVRDID
|
|
|
|---|
| BDBM50547346 |
|---|
| n/a |
|---|
| Name | BDBM50547346 |
|---|
| Synonyms: | CHEMBL3741215 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H28F3N3O2 |
|---|
| Mol. Mass. | 531.5681 |
|---|
| SMILES | Cc1ccc2occ(CN3CCN(Cc4cn(-c5cccc(c5)C(F)(F)F)c5ccccc45)CC3)c(=O)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
