| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
|---|
| Ligand | BDBM50331835 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2018974 (CHEMBL4672552) |
|---|
| Ki | 2.4±n/a nM |
|---|
| Citation |  Andring, JT; Fouch, M; Akocak, S; Angeli, A; Supuran, CT; Ilies, MA; McKenna, R Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. J Med Chem63:13064-13075 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 9 |
|---|
| Name: | Carbonic anhydrase 9 |
|---|
| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49669.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Catalytic domain of human cloned isozyme was used in the assay |
|---|
| Residue: | 459 |
|---|
| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
|---|
| BDBM50331835 |
|---|
| n/a |
|---|
| Name | BDBM50331835 |
|---|
| Synonyms: | 5-(2-methyl-propylamido)-2-sulfamoyl-1,3,4-thiadiazole | CHEMBL1288807 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H10N4O3S2 |
|---|
| Mol. Mass. | 250.299 |
|---|
| SMILES | CC(C)C(=O)Nc1nnc(s1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
