Reaction Details | |||
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Target | Disintegrin and metalloproteinase domain-containing protein 17 | ||
Ligand | BDBM50106670 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_206020 (CHEMBL810826) | ||
IC50 | 9±n/a nM | ||
Citation | Rabinowitz, MH; Andrews, RC; Becherer, JD; Bickett, DM; Bubacz, DG; Conway, JG; Cowan, DJ; Gaul, M; Glennon, K; Lambert, MH; Leesnitzer, MA; McDougald, DL; Moss, ML; Musso, DL; Rizzolio, MC Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). J Med Chem44:4252-67 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Disintegrin and metalloproteinase domain-containing protein 17 | |||
Name: | Disintegrin and metalloproteinase domain-containing protein 17 | ||
Synonyms: | ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE) | ||
Type: | Enzyme | ||
Mol. Mass.: | 93007.89 | ||
Organism: | Homo sapiens (Human) | ||
Description: | |||
Residue: | 824 | ||
Sequence: |
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BDBM50106670 | |||
n/a | |||
Name | BDBM50106670 | ||
Synonyms: | (2R,3R)-N-{(1R)-4-Nitroguanyl-1-[(1,3-thiazol-2-ylamino)carbonyl]butyl}-3-[formyl(hydroxy)amino]-2-[(4-cyclohexylmethyl)methyl]-hexanamide | CHEMBL335009 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H40N8O6S | ||
Mol. Mass. | 568.689 | ||
SMILES | CCC[C@@H]([C@@H](CC1CCC(C)CC1)C(=O)N[C@@H](CCCN=C(N)N[N+]([O-])=O)C(=O)Nc1nccs1)N(O)C=O |w:20.20,wU:4.13,wD:16.16,3.36,(1.62,-20.98,;1.62,-19.44,;2.95,-18.67,;2.95,-17.13,;4.28,-16.36,;4.28,-14.82,;5.05,-13.49,;4.25,-12.16,;5.02,-10.81,;6.56,-10.79,;7.33,-9.46,;7.35,-12.13,;6.59,-13.47,;5.61,-17.13,;5.61,-18.67,;6.95,-16.36,;8.28,-17.13,;8.28,-18.67,;9.62,-19.44,;9.62,-20.98,;10.95,-21.75,;10.95,-23.29,;12.28,-24.06,;9.62,-24.06,;9.62,-25.6,;8.28,-26.37,;10.95,-26.37,;9.62,-16.36,;9.62,-14.82,;10.95,-17.13,;12.28,-16.36,;13.7,-16.97,;14.72,-15.84,;13.95,-14.5,;12.44,-14.82,;1.62,-16.36,;.29,-17.13,;1.62,-14.82,;2.95,-14.05,)| | ||
Structure |