| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
|---|
| Ligand | BDBM50548458 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2022370 (CHEMBL4676183) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Panknin, O; Wagenfeld, A; Bone, W; Bender, E; Nowak-Reppel, K; Fernández-Montalván, AE; Nubbemeyer, R; Bäurle, S; Ring, S; Schmees, N; Prien, O; Schäfer, M; Friedrich, C; Zollner, TM; Steinmeyer, A; Mueller, T; Langer, G Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women. J Med Chem63:11854-11881 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gonadotropin-releasing hormone receptor |
|---|
| Name: | Gonadotropin-releasing hormone receptor |
|---|
| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37767.60 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1335047 |
|---|
| Residue: | 327 |
|---|
| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
|
|
|
|---|
| BDBM50548458 |
|---|
| n/a |
|---|
| Name | BDBM50548458 |
|---|
| Synonyms: | CHEMBL4756920 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27ClFN3O5S2 |
|---|
| Mol. Mass. | 604.112 |
|---|
| SMILES | Fc1ccc(cc1)S(=O)(=O)N1C(C2CC2)C2(CCS(=O)(=O)CC2)c2cc(ccc12)C(=O)NCc1ncccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
