| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP3 |
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| Ligand | BDBM50548685 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2022905 (CHEMBL4676718) |
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| IC50 | 8000±n/a nM |
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| Citation |  Karche, NP; Bhonde, M; Sinha, N; Jana, G; Kukreja, G; Kurhade, SP; Jagdale, AR; Tilekar, AR; Hajare, AK; Jadhav, GR; Gupta, NR; Limaye, R; Khedkar, N; Thube, BR; Shaikh, JS; Rao Irlapati, N; Phukan, S; Gole, G; Bommakanti, A; Khanwalkar, H; Pawar, Y; Kale, R; Kumar, R; Gupta, R; Praveen Kumar, VR; Wahid, S; Francis, A; Bhat, T; Kamble, N; Patil, V; Nigade, PB; Modi, D; Pawar, S; Naidu, S; Volam, H; Pagdala, V; Mallurwar, S; Goyal, H; Bora, P; Ahirrao, P; Singh, M; Kamalakannan, P; Naik, KR; Kumar, P; Powar, RG; Shankar, RB; Bernstein, PR; Gundu, J; Nemmani, K; Narasimham, L; George, KS; Sharma, S; Bakhle, D; Kamboj, RK; Palle, VP Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP3 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP3 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60091.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109545 |
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| Residue: | 533 |
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| Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
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| BDBM50548685 |
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| n/a |
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| Name | BDBM50548685 |
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| Synonyms: | CHEMBL4776820 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23N5O |
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| Mol. Mass. | 397.4723 |
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| SMILES | O=c1[nH]c(cc2ncccc12)C1=C[C@@H](CC1)N1CCN(CC1)c1ccc(cc1)C#N |r,t:13| |
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| Structure | 
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