| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50549908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2026002 (CHEMBL4679815) |
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| IC50 | 5.8±n/a nM |
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| Citation |  Schrader, TO; Xiong, Y; Lorenzana, AO; Broadhead, A; Stebbins, KJ; Poon, MM; Baccei, C; Lorrain, DS Discovery of PIPE-359, a Brain-Penetrant, Selective M ACS Med Chem Lett12:155-161 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50549908 |
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| n/a |
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| Name | BDBM50549908 |
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| Synonyms: | CHEMBL4760610 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3S2 |
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| Mol. Mass. | 441.527 |
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| SMILES | O=C(CCS(=O)(=O)c1cccc2ncsc12)N1CCN(CC1)c1ccc(cn1)C#N |
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| Structure | 
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