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TargetCarbonic anhydrase 12
LigandBDBM50551113
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2030254 (CHEMBL4684412)
Ki 14±n/a nM
Citation Said, MAEldehna, WMNocentini, AFahim, SHBonardi, AElgazar, AAKry?tof, VSoliman, DHAbdel-Aziz, HAGratteri, PAbou-Seri, SMSupuran, CT Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem189:0 (2020) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50551113
n/a
NameBDBM50551113
Synonyms:CHEMBL4790351
TypeSmall organic molecule
Emp. Form.C18H14N8O4S
Mol. Mass.438.42
SMILESNc1nn2c(ccnc2c1\N=N\c1ccc(cc1)S(N)(=O)=O)-c1ccc(cc1)[N+]([O-])=O
Structure
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