| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50111663 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209063 |
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| Ki | 10±n/a nM |
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| Citation |  St-Denis, Y; Lévesque, S; Bachand, B; Edmunds, JJ; Leblond, L; Préville, P; Tarazi, M; Winocour, PD; Siddiqui, MA Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors. Bioorg Med Chem Lett12:1181-4 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50111663 |
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| n/a |
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| Name | BDBM50111663 |
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| Synonyms: | (6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid (6-amino-2-methyl-pyridin-3-ylmethyl)-amide | CHEMBL17793 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31N5O4S |
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| Mol. Mass. | 533.642 |
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| SMILES | Cc1nc(N)ccc1CNC(=O)[C@@H]1CC[C@H]2CN(CC(=O)N12)S(=O)(=O)C(c1ccccc1)c1ccccc1 |
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| Structure | 
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