Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Ligand | BDBM50314706 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2034043 (CHEMBL4688201) |
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Ki | 6.0±n/a nM |
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Citation | Du, L; Wang, X; Cui, G; Xu, B Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors. Bioorg Med Chem29:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Name: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Synonyms: | PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Type: | PROTEIN |
Mol. Mass.: | 18248.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1502595 |
Residue: | 163 |
Sequence: | MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL
LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG
DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
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BDBM50314706 |
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n/a |
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Name | BDBM50314706 |
Synonyms: | (R)-2-(2-naphthamido)-5-(3-fluorophenyl)pent-4-enoic acid | CHEMBL1090715 |
Type | Small organic molecule |
Emp. Form. | C22H18FNO3 |
Mol. Mass. | 363.3816 |
SMILES | OC(=O)[C@@H](C\C=C\c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 |r| |
Structure |
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