| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK3 |
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| Ligand | BDBM50552555 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2035043 (CHEMBL4689201) |
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| IC50 | 1280±n/a nM |
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| Citation |  Brahmaiah, D; Kanaka Durga Bhavani, A; Aparna, P; Sampath Kumar, N; Solhi, H; Le Guevel, R; Baratte, B; Ruchaud, S; Bach, S; Singh Jadav, S; Raji Reddy, C; Roisnel, T; Mosset, P; Levoin, N; Grée, R Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase. Bioorg Med Chem31:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK3 |
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| Name: | Dual specificity protein kinase CLK3 |
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| Synonyms: | CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3 |
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| Type: | Protein |
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| Mol. Mass.: | 73570.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 638 |
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| Sequence: | MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGG
GPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGL
PRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEG
RLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHR
RRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWL
QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD
KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT
TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRM
LEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
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| BDBM50552555 |
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| n/a |
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| Name | BDBM50552555 |
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| Synonyms: | CHEMBL4783398 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18ClN7O3 |
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| Mol. Mass. | 487.898 |
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| SMILES | Cc1ccc(c(c1)[N+]([O-])=O)-n1cc(COc2cccc3cnc(Nc4cccc(Cl)c4)nc23)nn1 |
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| Structure | 
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