Reaction Details |
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Target | Cytochrome P450 2C19 |
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Ligand | BDBM50553249 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2045772 (CHEMBL4700471) |
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IC50 | 800±n/a nM |
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Citation | Kirk, R; Ratcliffe, A; Noonan, G; Uosis-Martin, M; Lyth, D; Bardell-Cox, O; Massam, J; Schofield, P; Hindley, S; Jones, DR; Maclean, J; Smith, A; Savage, V; Mohmed, S; Charrier, C; Salisbury, AM; Moyo, E; Metzger, R; Chalam-Judge, N; Cheung, J; Stokes, NR; Best, S; Craighead, M; Armer, R; Huxley, A Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1. RSC Med Chem11:1366-1378 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C19 |
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Name: | Cytochrome P450 2C19 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
Type: | Enzyme |
Mol. Mass.: | 55935.47 |
Organism: | Homo sapiens (Human) |
Description: | P33261 |
Residue: | 490 |
Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50553249 |
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n/a |
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Name | BDBM50553249 |
Synonyms: | CHEMBL4743440 |
Type | Small organic molecule |
Emp. Form. | C22H19N5O2 |
Mol. Mass. | 385.4186 |
SMILES | Cc1c(ccc2c3oc(CN)nc3c(=O)n(C3CC3)c12)-c1ccc2[nH]ncc2c1 |
Structure |
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