| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM50504019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2049316 (CHEMBL4704015) |
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| IC50 | 87±n/a nM |
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| Citation |  Koralewski, R; Dymek, B; Mazur, M; Sklepkiewicz, P; Olejniczak, S; Czestkowski, W; Matyszewski, K; Andryianau, G; Niedziejko, P; Kowalski, M; Gruza, M; Borek, B; Jedrzejczak, K; Bartoszewicz, A; Pluta, E; Rymaszewska, A; Kania, M; Rejczak, T; Piasecka, S; Mlacki, M; Mazurkiewicz, M; Piotrowicz, M; Salamon, M; Zagozdzon, A; Napiorkowska-Gromadzka, A; Bartlomiejczak, A; Mozga, W; Dobrza?ski, P; Dzwonek, K; Golab, J; Nowotny, M; Olczak, J; Golebiowski, A Discovery of J Med Chem63:15527-15540 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | 3.2.1.14 | CHIT1_MOUSE | Chit1 | Chitinase-1 | Chitotriosidase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51108.04 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117450 |
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| Residue: | 464 |
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| Sequence: | MVQSLAWAGVMTLLMVQWGSAAKLVCYLTNWSQYRTEAVRFFPRDVDPNLCTHVIFAFAG
MDNHQLSTVEHNDELLYQELNSLKTKNPKLKTLLAVGGWTFGTQKFTDMVATASNRQTFV
KSALSFLRTQGFDGLDLDWEFPGGRGSPTVDKERFTALIQDLAKAFQEEAQSSGKERLLL
TAAVPSDRGLVDAGYEVDKIAQSLDFINLMAYDFHSSLEKTTGHNSPLYKRQGESGAAAE
QNVDAAVTLWLQKGTPASKLILGMPTYGRSFTLASSSDNGVGAPATGPGAPGPYTKDKGV
LAYYEACSWKERHRIEDQKVPYAFQDNQWVSFDDVESFKAKAAYLKQKGLGGAMVWVLDL
DDFKGSFCNQGPYPLIRTLRQELNLPSETPRSPEQIIPEPRPSSMPEQGPSPGLDNFCQG
KADGVYPNPGDESTYYNCGGGRLFQQSCPPGLVFRASCKCCTWS
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| BDBM50504019 |
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| n/a |
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| Name | BDBM50504019 |
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| Synonyms: | CHEMBL4580568 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27ClN6 |
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| Mol. Mass. | 374.911 |
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| SMILES | Nc1n[nH]c(n1)N1CCC(CC1)N1CCCC[C@@H]1Cc1ccc(Cl)cc1 |r| |
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| Structure | 
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