| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 5 |
|---|
| Ligand | BDBM50116044 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_92217 |
|---|
| Ki | 18000±n/a nM |
|---|
| Citation |  Lubisch, W; Behl, B; Henn, C; Hofmann, HP; Reeb, J; Regner, F; Vierling, M Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5. Bioorg Med Chem Lett12:2113-6 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor ionotropic, kainate 5 |
|---|
| Name: | Glutamate receptor ionotropic, kainate 5 |
|---|
| Synonyms: | GRIK2 | GRIK5 | GRIK5_HUMAN | Glutamate receptor ionotropic kainate 5 | Glutamate receptor, ionotropic kainate 5 | Glutamate-Kainate 5 | Ionotropic glutamate receptor kainate 2/5 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 109280.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glutamate-Kainate 5 Grik5 HUMAN::Q16478 |
|---|
| Residue: | 980 |
|---|
| Sequence: | MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK
ARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKV
GPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRG
FLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFY
KYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGP
ALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTG
RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVT
TILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGS
WTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLD
PFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPV
GGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD
QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFL
LESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR
KWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVS
VCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAG
SAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEA
TSPPRPRPGPAGPRELAEHE
|
|
|
|---|
| BDBM50116044 |
|---|
| n/a |
|---|
| Name | BDBM50116044 |
|---|
| Synonyms: | CHEMBL416685 | {6-Nitro-2,3-dioxo-7-[3-(4-phenyl-piperidin-1-ylmethyl)-pyrrol-1-yl]-3,4-dihydro-2H-quinoxalin-1-yl}-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25N5O6 |
|---|
| Mol. Mass. | 503.5066 |
|---|
| SMILES | OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)[N+]([O-])=O)-n1ccc(CN2CCC(CC2)c2ccccc2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
