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Reaction Details
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TargetSubstance-K receptor
LigandBDBM50116645
Substrate/Competitorn/a
Meas. Tech.ChEBML_209037
Ki 790.0±n/a nM
Citation Capozzi, G; Giannini, S; Menichetti, S; Nativi, C; Giolitti, A; Patacchini, R; Perrotta, E; Altamura, M; Alberto Maggi, C Design, synthesis and biological activity of carbohydrate-containing peptidomimetics as new ligands for the human tachykinin NK-2 receptor. Bioorg Med Chem Lett12:2263-6 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Substance-K receptor
Name:Substance-K receptor
Synonyms:NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:Protein
Mol. Mass.:44455.78
Organism:Homo sapiens (Human)
Description:P21452
Residue:398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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  Blast E-value cutoff:
BDBM50116645
n/a
NameBDBM50116645
Synonyms:(7,8-Bis-benzyloxy-6-benzyloxymethyl-1-oxo-3-phenyl-6,7,8,8a-tetrahydro-1H,4aH-4,5-dioxa-1lambda*4*-thia-naphthalen-2-yl)-phenyl-methanone | CHEMBL308177
TypeSmall organic molecule
Emp. Form.C42H36O7S
Mol. Mass.684.796
SMILESO=C(C1=C(OC2=C(C(OCc3ccccc3)C(OCc3ccccc3)C(COCc3ccccc3)O2)S1=O)c1ccccc1)c1ccccc1 |t:2,5,(10.41,-7.68,;11.83,-8.31,;13.07,-7.4,;13.93,-7.57,;15.03,-6.49,;14.63,-5,;13.45,-4.58,;11.74,-5.19,;10.2,-5.19,;8.97,-6.14,;7.54,-5.56,;7.35,-4.04,;5.93,-3.45,;4.71,-4.39,;4.91,-5.91,;6.35,-6.51,;10.97,-3.85,;9.92,-2.71,;8.52,-2.08,;8.35,-.56,;9.61,.34,;9.45,1.88,;8.03,2.5,;6.79,1.59,;6.95,.06,;12.23,-4.27,;12.23,-2.73,;13.56,-1.94,;13.54,-.4,;14.87,.37,;16.22,-.4,;17.55,.39,;17.53,1.93,;16.19,2.68,;14.86,1.91,;13.87,-3.65,;12.67,-5.91,;11.34,-6.67,;15.03,-8.66,;14.61,-10.15,;15.7,-11.23,;17.2,-10.83,;17.58,-9.34,;16.5,-8.26,;11.99,-9.83,;13.52,-10.06,;14.08,-11.49,;13.12,-12.7,;11.6,-12.47,;11.04,-11.04,)|
Structure
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