| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XII |
|---|
| Ligand | BDBM50104435 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2055303 (CHEMBL4710304) |
|---|
| Ki | 2920±n/a nM |
|---|
| Citation |  Davoine, C; Bouckaert, C; Fillet, M; Pochet, L Factor XII/XIIa inhibitors: Their discovery, development, and potential indications. Eur J Med Chem208:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XII |
|---|
| Name: | Coagulation factor XII |
|---|
| Synonyms: | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67810.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00748 |
|---|
| Residue: | 615 |
|---|
| Sequence: | MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS
|
|
|
|---|
| BDBM50104435 |
|---|
| n/a |
|---|
| Name | BDBM50104435 |
|---|
| Synonyms: | 4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl ester | CHEMBL87563 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H23N3O4 |
|---|
| Mol. Mass. | 321.3715 |
|---|
| SMILES | CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
