| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Choline kinase alpha |
|---|
| Ligand | BDBM50556491 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2056236 (CHEMBL4711237) |
|---|
| Kd | 370±n/a nM |
|---|
| Citation |  Serrán-Aguilera, L; Mariotto, E; Rubbini, G; Castro Navas, FF; Marco, C; Carrasco-Jiménez, MP; Ballarotto, M; Macchiarulo, A; Hurtado-Guerrero, R; Viola, G; Lopez-Cara, LC Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism. Eur J Med Chem207:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Choline kinase alpha |
|---|
| Name: | Choline kinase alpha |
|---|
| Synonyms: | CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52248.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1290064 |
|---|
| Residue: | 457 |
|---|
| Sequence: | MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
|
|
|
|---|
| BDBM50556491 |
|---|
| n/a |
|---|
| Name | BDBM50556491 |
|---|
| Synonyms: | CHEMBL4784458 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H28BrClN2 |
|---|
| Mol. Mass. | 507.892 |
|---|
| SMILES | [Br-].Clc1ccc2c(cc[n+](Cc3ccc(cc3)-c3ccccc3)c2c1)N1CCCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
