| Reaction Details |
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 | Report a problem with these data |
| Target | Choline kinase alpha |
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| Ligand | BDBM50556492 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2056242 (CHEMBL4711243) |
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| IC50 | 12550±n/a nM |
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| Citation |  Serrán-Aguilera, L; Mariotto, E; Rubbini, G; Castro Navas, FF; Marco, C; Carrasco-Jiménez, MP; Ballarotto, M; Macchiarulo, A; Hurtado-Guerrero, R; Viola, G; Lopez-Cara, LC Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism. Eur J Med Chem207:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Choline kinase alpha |
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| Name: | Choline kinase alpha |
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| Synonyms: | CHK | CHKA | CHKA_HUMAN | CKI | Choline kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52248.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290064 |
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| Residue: | 457 |
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| Sequence: | MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPP
PPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGL
SNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLE
SVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKM
PFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPV
VFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLW
GLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
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| BDBM50556492 |
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| n/a |
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| Name | BDBM50556492 |
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| Synonyms: | CHEMBL4747352 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24BrClN2 |
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| Mol. Mass. | 515.871 |
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| SMILES | [Br-].CN(c1ccccc1)c1cc[n+](Cc2ccc(cc2)-c2ccccc2)c2cc(Cl)ccc12 |
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| Structure | 
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