| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM50117485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_214876 (CHEMBL872576) |
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| IC50 | 390±n/a nM |
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| Citation |  Kondo, K; Kan, K; Tanada, Y; Bando, M; Shinohara, T; Kurimura, M; Ogawa, H; Nakamura, S; Hirano, T; Yamamura, Y; Kido, M; Mori, T; Tominaga, M Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide. J Med Chem45:3805-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | AVPR V2 | Antidiuretic hormone receptor | Avpr2 | Renal-type arginine vasopressin receptor | V2R_RAT | VASOPRESSIN V2 | Vasopressin receptor |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 40761.85 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 371 |
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| Sequence: | MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLG
ALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQ
RDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGP
SERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEA
PLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCAT
ASSSLMKDTPS
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| BDBM50117485 |
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| n/a |
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| Name | BDBM50117485 |
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| Synonyms: | 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-N-isopropyl-acetamide | CHEMBL125878 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32ClN3O2 |
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| Mol. Mass. | 454.004 |
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| SMILES | CC(C)NC(=O)C[C@@H]1CCCN(C(=O)c2ccc(cc2Cl)N2CCCC2)c2ccccc12 |
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| Structure | 
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