Reaction Details |
| Report a problem with these data |
Target | Monoglyceride lipase |
---|
Ligand | BDBM50556543 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2056357 (CHEMBL4711358) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Arena, C; Gado, F; Di Cesare Mannelli, L; Cervetto, C; Carpi, S; Reynoso-Moreno, I; Polini, B; Vallini, E; Chicca, S; Lucarini, E; Bertini, S; D'Andrea, F; Digiacomo, M; Poli, G; Tuccinardi, T; Macchia, M; Gertsch, J; Marcoli, M; Nieri, P; Ghelardini, C; Chicca, A; Manera, C The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. Eur J Med Chem208:0 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Monoglyceride lipase |
---|
Name: | Monoglyceride lipase |
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
Type: | Hydrolase |
Mol. Mass.: | 33264.56 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
Residue: | 303 |
Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
|
|
BDBM50556543 |
---|
n/a |
---|
Name | BDBM50556543 |
Synonyms: | CHEMBL4753784 |
Type | Small organic molecule |
Emp. Form. | C28H31FN2O3 |
Mol. Mass. | 462.5557 |
SMILES | COc1ccc(cc1)-c1cc(C(=O)NC2CCCCCC2)c(OCc2ccc(F)cc2)nc1C |
Structure |
|