| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50117513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205874 |
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| IC50 | 30±n/a nM |
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| Citation |  Seward, EM; Carlson, E; Harrison, T; Haworth, KR; Herbert, R; Kelleher, FJ; Kurtz, MM; Moseley, J; Owen, SN; Owens, AP; Sadowski, SJ; Swain, CJ; Williams, BJ Spirocyclic NK(1) antagonists I: [4.5] and [5.5]-spiroketals. Bioorg Med Chem Lett12:2515-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50117513 |
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| n/a |
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| Name | BDBM50117513 |
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| Synonyms: | (3S,5S,10S)-5-(4-Fluoro-phenyl)-10-(3-trifluoromethyl-phenyl)-1,8-dioxa-4-aza-spiro[5.5]undecane | CHEMBL82220 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F4NO2 |
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| Mol. Mass. | 395.3906 |
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| SMILES | Fc1ccc(cc1)[C@@H]1NCCOC11COC[C@@H](C1)c1cccc(c1)C(F)(F)F |
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| Structure | 
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