| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 6 |
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| Ligand | BDBM50556732 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2057042 (CHEMBL4712043) |
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| IC50 | 130±n/a nM |
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| Citation |  Mostinski, Y; Heynen, GJJE; López-Alberca, MP; Paul, J; Miksche, S; Radetzki, S; Schaller, D; Shanina, E; Seyffarth, C; Kolomeets, Y; Ziebart, N; de Schryver, J; Oestreich, S; Neuenschwander, M; Roske, Y; Heinemann, U; Rademacher, C; Volkamer, A; von Kries, JP; Birchmeier, W; Nazaré, M From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem63:14780-14804 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 6 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 6 |
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| Synonyms: | HCP | PTN6_HUMAN | PTP1C | PTPN6 | Protein tyrosine phosphatase SHP-1 (SHP-1) | Protein-tyrosine phosphatase 1C | Protein-tyrosine phosphatase SHP-1 | Src homology phosphatase 1 (SHP-1) | Tyrosine-protein phosphatase non-receptor type 6 | Tyrosine-protein phosphatase non-receptor type 6 (SHP1) |
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| Type: | Protein |
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| Mol. Mass.: | 67570.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29350 |
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| Residue: | 595 |
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| Sequence: | MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF
YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA
ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG
LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA
KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD
YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK
CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH
GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC
DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT
YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
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| BDBM50556732 |
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| n/a |
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| Name | BDBM50556732 |
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| Synonyms: | CHEMBL4750435 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H20N2O5 |
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| Mol. Mass. | 488.4902 |
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| SMILES | COc1ccc(cc1)-n1cc(-c2ccc3ccc(=O)oc3c2)c2cc(cnc12)-c1ccc(cc1)C(O)=O |
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| Structure | 
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