Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 12 |
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Ligand | BDBM50556732 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2057047 (CHEMBL4712048) |
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IC50 | 130±n/a nM |
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Citation | Mostinski, Y; Heynen, GJJE; López-Alberca, MP; Paul, J; Miksche, S; Radetzki, S; Schaller, D; Shanina, E; Seyffarth, C; Kolomeets, Y; Ziebart, N; de Schryver, J; Oestreich, S; Neuenschwander, M; Roske, Y; Heinemann, U; Rademacher, C; Volkamer, A; von Kries, JP; Birchmeier, W; Nazaré, M From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem63:14780-14804 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 12 |
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Name: | Tyrosine-protein phosphatase non-receptor type 12 |
Synonyms: | PTN12_HUMAN | PTP-PEST | PTPG1 | PTPN12 | Protein-tyrosine phosphatase G1 | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST) |
Type: | Protein |
Mol. Mass.: | 88089.78 |
Organism: | Homo sapiens (Human) |
Description: | Q05209 |
Residue: | 780 |
Sequence: | MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVK
KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGA
ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
YEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNE
STIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQE
LSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNP
LHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTH
SGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSE
NEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
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BDBM50556732 |
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n/a |
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Name | BDBM50556732 |
Synonyms: | CHEMBL4750435 |
Type | Small organic molecule |
Emp. Form. | C30H20N2O5 |
Mol. Mass. | 488.4902 |
SMILES | COc1ccc(cc1)-n1cc(-c2ccc3ccc(=O)oc3c2)c2cc(cnc12)-c1ccc(cc1)C(O)=O |
Structure |
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