Reaction Details |
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Target | Activin receptor type-1 |
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Ligand | BDBM50557476 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2059249 (CHEMBL4714250) |
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IC50 | 18±n/a nM |
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Citation | Yamamoto, H; Sakai, N; Ohte, S; Sato, T; Sekimata, K; Matsumoto, T; Nakamura, K; Watanabe, H; Mishima-Tsumagari, C; Tanaka, A; Hashizume, Y; Honma, T; Katagiri, T; Miyazono, K; Tomoda, H; Shirouzu, M; Koyama, H Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva. Bioorg Med Chem Lett38:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-1 |
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Name: | Activin receptor type-1 |
Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
Type: | n/a |
Mol. Mass.: | 57158.32 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 509 |
Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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BDBM50557476 |
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n/a |
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Name | BDBM50557476 |
Synonyms: | CHEMBL4748071 |
Type | Small organic molecule |
Emp. Form. | C28H32N8O2 |
Mol. Mass. | 512.6061 |
SMILES | COCCN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c3COCCn3nc2-c2cccnc2)cc1 |
Structure |
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