Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50118771 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_162283 (CHEMBL770981) |
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pH | 5.5±n/a |
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Ki | 2000±n/a nM |
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Comments | extracted |
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Citation | Andersen, HS; Olsen, OH; Iversen, LF; Sørensen, AL; Mortensen, SB; Christensen, MS; Branner, S; Hansen, TK; Lau, JF; Jeppesen, L; Moran, EJ; Su, J; Bakir, F; Judge, L; Shahbaz, M; Collins, T; Vo, T; Newman, MJ; Ripka, WC; Møller, NP Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J Med Chem45:4443-59 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50118771 |
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n/a |
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Name | BDBM50118771 |
Synonyms: | 2-(carboxyformamido)-6-hydroxy-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | 6-Hydroxy-2-(oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid | CHEMBL139356 |
Type | Small organic molecule |
Emp. Form. | C11H11NO6S |
Mol. Mass. | 285.273 |
SMILES | OC1CCc2c(C1)sc(NC(=O)C(O)=O)c2C(O)=O |
Structure |
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