| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 17B |
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| Ligand | BDBM50559233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2068504 (CHEMBL4723757) |
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| IC50 | 14±n/a nM |
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| Citation |  Picado, A; Chaikuad, A; Wells, CI; Shrestha, S; Zuercher, WJ; Pickett, JE; Kwarcinski, FE; Sinha, P; de Silva, CS; Zutshi, R; Liu, S; Kannan, N; Knapp, S; Drewry, DH; Willson, TM A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem63:14626-14646 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 17B |
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| Name: | Serine/threonine-protein kinase 17B |
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| Synonyms: | DRAK2 | ST17B_HUMAN | STK17B | Serine/threonine-protein kinase 17B | Serine/threonine-protein kinase 17B (STK17B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42332.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O94768 |
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| Residue: | 372 |
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| Sequence: | MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYA
AKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFS
LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF
GMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN
QETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFEN
LFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSL
PNPHELVSDLLC
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| BDBM50559233 |
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| n/a |
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| Name | BDBM50559233 |
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| Synonyms: | CHEMBL4753926 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N3O3S2 |
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| Mol. Mass. | 387.476 |
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| SMILES | OC(=O)CSc1ncnc2cc(sc12)-c1ccc(cc1)N1CCOCC1 |
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| Structure | 
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