Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-2 | ||
Ligand | BDBM106801 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2068631 (CHEMBL4723884) | ||
Ki | 4.0±n/a nM | ||
Citation | Han, W; Ding, Y; Chen, Z; Langowski, JL; Bellamacina, C; Rico, A; Nishiguchi, GA; Lan, J; Atallah, G; Lindvall, M; Lin, S; Zang, R; Feucht, P; Zavorotinskaya, T; Dai, Y; Garcia, P; Burger, MT Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases. J Med Chem63:14885-14904 (2020) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-2 | |||
Name: | Serine/threonine-protein kinase pim-2 | ||
Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 34185.93 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9P1W9 | ||
Residue: | 311 | ||
Sequence: |
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BDBM106801 | |||
n/a | |||
Name | BDBM106801 | ||
Synonyms: | US8592455, 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H22F3N3O2 | ||
Mol. Mass. | 441.4456 | ||
SMILES | C[C@@H]1C[C@H](O)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:6.8,3.3,1.0,(-.67,2.69,;-2,1.93,;-3.33,2.69,;-4.67,1.93,;-6,2.69,;-4.67,.38,;-3.33,-.38,;-2,.38,;-3.33,-1.93,;-4.67,-2.69,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;.67,-4.23,;2,-1.93,;3.33,-2.69,;4.67,-1.93,;4.67,-.38,;6,.38,;3.33,.38,;2,-.38,;3.33,1.93,;2,2.69,;.67,1.93,;2,4.23,;3.33,5,;4.67,4.23,;4.67,2.69,;6,1.93,)| | ||
Structure |