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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 7 | ||
| Ligand | BDBM50559469 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2069570 (CHEMBL4724823) | ||
| IC50 | 89±n/a nM | ||
| Citation |  Sato, M; Kondo, T; Kohno, Y; Seto, S Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model. Bioorg Med Chem34:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 7 | |||
| Name: | Mitogen-activated protein kinase 7 | ||
| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 | ||
| Type: | Protein | ||
| Mol. Mass.: | 88377.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13164 | ||
| Residue: | 816 | ||
| Sequence: |
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| BDBM50559469 | |||
| n/a | |||
| Name | BDBM50559469 | ||
| Synonyms: | CHEMBL4788469 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H24N4O2 | ||
| Mol. Mass. | 352.4302 | ||
| SMILES | CN1c2ccccc2C(=O)N(C)c2cnc(N[C@H]3CC[C@H](O)CC3)cc12 |r,wU:17.17,wD:20.21,(8.15,-8.03,;8.47,-6.53,;9.98,-6.17,;10.87,-7.43,;12.41,-7.3,;13.06,-5.89,;12.17,-4.63,;10.64,-4.77,;9.96,-3.38,;10.91,-2.17,;8.45,-3.05,;8.09,-1.56,;7.24,-4.03,;5.91,-3.27,;4.59,-4.04,;4.59,-5.58,;3.26,-6.35,;3.25,-7.88,;4.59,-8.65,;4.58,-10.19,;3.25,-10.95,;3.24,-12.49,;1.92,-10.18,;1.93,-8.65,;5.92,-6.35,;7.25,-5.57,)| | ||
| Structure | 
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