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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 7 | ||
| Ligand | BDBM50559474 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2069575 (CHEMBL4724828) | ||
| IC50 | 393±n/a nM | ||
| Citation |  Sato, M; Kondo, T; Kohno, Y; Seto, S Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model. Bioorg Med Chem34:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 7 | |||
| Name: | Mitogen-activated protein kinase 7 | ||
| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 | ||
| Type: | Protein | ||
| Mol. Mass.: | 88377.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13164 | ||
| Residue: | 816 | ||
| Sequence: |
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| BDBM50559474 | |||
| n/a | |||
| Name | BDBM50559474 | ||
| Synonyms: | CHEMBL4790464 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H20FN3O3 | ||
| Mol. Mass. | 357.3788 | ||
| SMILES | CN1c2cnc(N[C@H]3CC[C@H](O)CC3)cc2Oc2c(F)cccc2C1=O |r,wU:7.6,wD:10.10,(8.39,-31.5,;8.74,-32.99,;7.54,-33.97,;6.21,-33.21,;4.88,-33.97,;4.88,-35.51,;3.55,-36.28,;3.55,-37.82,;4.88,-38.58,;4.87,-40.12,;3.54,-40.89,;3.53,-42.42,;2.22,-40.11,;2.22,-38.58,;6.21,-36.28,;7.55,-35.51,;8.77,-36.47,;10.28,-36.1,;11.17,-37.37,;10.52,-38.76,;12.71,-37.23,;13.36,-35.82,;12.47,-34.56,;10.93,-34.7,;10.26,-33.31,;11.2,-32.1,)| | ||
| Structure | 
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