Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 7 | ||
| Ligand | BDBM50559479 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2069575 (CHEMBL4724828) | ||
| IC50 | 2230±n/a nM | ||
| Citation |  Sato, M; Kondo, T; Kohno, Y; Seto, S Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model. Bioorg Med Chem34:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 7 | |||
| Name: | Mitogen-activated protein kinase 7 | ||
| Synonyms: | BMK1 | Big MAP kinase 1 | ERK5 | Extracellular signal-regulated kinase 5 (ERK5) | MAPK7 | MK07_HUMAN | PRKM7 | ||
| Type: | Protein | ||
| Mol. Mass.: | 88377.36 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13164 | ||
| Residue: | 816 | ||
| Sequence: |
| ||
| BDBM50559479 | |||
| n/a | |||
| Name | BDBM50559479 | ||
| Synonyms: | CHEMBL4747052 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H24N4O2 | ||
| Mol. Mass. | 352.4302 | ||
| SMILES | CN1c2ccccc2C(=O)N(C)c2cnc(N[C@@H]3CC[C@H](O)CC3)cc12 |r,wU:17.17,20.21,(39.97,-8.02,;40.3,-6.52,;41.81,-6.15,;42.69,-7.42,;44.23,-7.28,;44.88,-5.87,;43.99,-4.61,;42.46,-4.75,;41.78,-3.36,;42.73,-2.15,;40.27,-3.04,;39.91,-1.55,;39.07,-4.02,;37.74,-3.26,;36.41,-4.02,;36.41,-5.56,;35.08,-6.33,;35.08,-7.87,;33.75,-8.63,;33.74,-10.16,;35.07,-10.94,;35.06,-12.47,;36.4,-10.17,;36.41,-8.63,;37.74,-6.33,;39.08,-5.56,)| | ||
| Structure | 
| ||