Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50559607

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2069852 (CHEMBL4725105)

EC50

1244±n/a nM

Citation

Ma, B; Guckian, KM; Liu, XG; Yang, C; Li, B; Scannevin, R; Mingueneau, M; Drouillard, A; Walzer, T Novel Potent Selective Orally Active S1P5 Receptor Antagonists. ACS Med Chem Lett12:351-355 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50559607

n/a

Name

BDBM50559607

Synonyms:

CHEMBL4764896

Type

Small organic molecule

Emp. Form.

C26H35NO3

Mol. Mass.

409.561

SMILES

CC[C@H]1CC[C@H](CC1)Oc1cc(C)c2ccccc2c1CN1CCC(CC1)C(O)=O |r,wU:5.8,2.1,(11.48,-7.6,;12.81,-6.84,;14.14,-7.61,;15.48,-6.85,;16.8,-7.62,;16.79,-9.17,;15.47,-9.94,;14.13,-9.16,;18.13,-9.94,;19.46,-9.17,;19.46,-7.63,;20.79,-6.86,;20.79,-5.32,;22.13,-7.62,;23.45,-6.85,;24.79,-7.61,;24.8,-9.16,;23.46,-9.93,;22.13,-9.17,;20.79,-9.94,;20.8,-11.48,;22.13,-12.25,;22.13,-13.79,;23.46,-14.56,;24.8,-13.79,;24.8,-12.25,;23.46,-11.47,;26.13,-14.56,;27.46,-13.79,;26.13,-16.1,)|

Structure