Ki Summary

Reaction Details

Report a problem with these data

Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50559620

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2069852 (CHEMBL4725105)

EC50

>5000±n/a nM

Citation

Ma, B; Guckian, KM; Liu, XG; Yang, C; Li, B; Scannevin, R; Mingueneau, M; Drouillard, A; Walzer, T Novel Potent Selective Orally Active S1P5 Receptor Antagonists. ACS Med Chem Lett12:351-355 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50559620

n/a

Name

BDBM50559620

Synonyms:

CHEMBL4744077

Type

Small organic molecule

Emp. Form.

C27H37NO3

Mol. Mass.

423.5876

SMILES

Cc1cc(O[C@H]2CC[C@@H](CC2)C(C)(C)C)c(CN2CC(CC(O)=O)C2)c2ccccc12 |r,wU:8.11,wD:5.4,(11.68,-4.8,;11.69,-6.34,;10.36,-7.11,;10.36,-8.65,;9.02,-9.42,;7.69,-8.65,;7.7,-7.1,;6.37,-6.33,;5.03,-7.09,;5.03,-8.64,;6.36,-9.42,;3.7,-6.32,;3.71,-4.78,;2.36,-7.08,;2.36,-5.55,;11.69,-9.42,;11.69,-10.96,;13.03,-11.73,;13.44,-13.21,;14.92,-12.81,;16.26,-13.58,;16.26,-15.12,;17.6,-15.88,;14.93,-15.89,;14.52,-11.32,;13.02,-8.65,;14.36,-9.41,;15.69,-8.64,;15.68,-7.09,;14.35,-6.33,;13.02,-7.1,)|

Structure