Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50559625

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2069852 (CHEMBL4725105)

EC50

1.4±n/a nM

Citation

Ma, B; Guckian, KM; Liu, XG; Yang, C; Li, B; Scannevin, R; Mingueneau, M; Drouillard, A; Walzer, T Novel Potent Selective Orally Active S1P5 Receptor Antagonists. ACS Med Chem Lett12:351-355 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50559625

n/a

Name

BDBM50559625

Synonyms:

CHEMBL4778095

Type

Small organic molecule

Emp. Form.

C26H37NO3

Mol. Mass.

411.5769

SMILES

Cc1cc(O[C@H]2CC[C@@H](CC2)C(C)(C)C)c(CNCCCC(O)=O)c2ccccc12 |r,wU:8.11,wD:5.4,(11.95,-5.46,;11.95,-7,;10.62,-7.77,;10.62,-9.31,;9.29,-10.08,;7.95,-9.31,;7.96,-7.76,;6.64,-6.99,;5.3,-7.76,;5.29,-9.3,;6.63,-10.08,;3.97,-6.98,;3.97,-5.44,;2.63,-7.74,;2.62,-6.21,;11.95,-10.08,;11.96,-11.62,;13.29,-12.39,;13.3,-13.93,;14.63,-14.7,;14.64,-16.24,;15.97,-17.01,;15.97,-18.55,;17.3,-16.23,;13.29,-9.31,;14.62,-10.07,;15.96,-9.3,;15.95,-7.75,;14.61,-6.99,;13.29,-7.76,)|

Structure